Campral (acamprosate calcium) tablets label
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چکیده
CAMPRAL (acamprosate calcium) is supplied in an enteric-coated tablet for oral administration. Acamprosate calcium is a synthetic compound with a chemical structure similar to that of the endogenous amino acid homotaurine, which is a structural analogue of the amino acid neurotransmitter γ-aminobutyric acid and the amino acid neuromodulator taurine. Its chemical name is calcium acetylaminopropane sulfonate. Its chemical formula is C10H20N2O8S2Ca and molecular weight is 400.48. Its structural formula is:
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Acamprosate Calcium (Campral®): An Effective Treatment for Maintaining Abstinence in Alcohol-Dependent Patients in Combination with Psychosocial Support
INTRODUCTION On July 29, 2004, acamprosate calcium (Campral® Delayed-Release Tablets, Lipha/Forest), a glutamate receptor modulator, gained the U.S. Food and Drug Administration’s (FDA’s) approval for the maintenance of abstinence from alcohol in alcohol-dependent patients who are abstinent at the time of treatment initiation. This is the first new medication in this category for the treatment ...
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Developing pharmacotherapies to treat alcohol dependence and associated health problems traditionally has been based on gaining a better understanding of the neuroscience underlying alcohol-drinking behavior. To date, three medications have been approved for the treatment of alcohol dependence: disulfiram (Antabuse®), naltrexone (Revia®, Vivitrol®, and Naltrel®), and acamprosate (Campral®). How...
متن کاملKinetic study of acamprosate absorption in rat small intestine.
Acamprosate (calcium bis acetyl-homotaurine), a homotaurine derivative, a structural analogue of gamma-aminobutyric acid (GABA) and an upper homologue of taurine, is a relatively new drug used to prevent relapse in weaned alcoholics. When administered orally as enteric-coated tablets at relatively high doses, this drug has a bioavailability of about 11%; however, the intestinal absorption mecha...
متن کاملEfficacy of acamprosate in the treatment of alcohol-dependent outpatients.
OBJECTIVE To evaluate the efficacy and security of acamprosate in the treatment of 75 men, aged 18 to 59 years, with diagnosis of alcohol dependence according to the ICD-10. METHODS Double-blind, placebo-controlled study, 24-week long. After a one-week detoxification period, patients were randomly divided in two groups: the first group received acamprosate (six tablets of 333 mg/d for 12 week...
متن کاملSafety and Efficacy of Acamprosate for the Treatment of Alcohol Dependence
Acamprosate (calcium acetylhomotaurine) is an amino acid modulator that has displayed efficacy in some clinical trials in reducing craving and promoting abstinence in alcohol dependent patients following detoxification. While acamprosate is safe and generally well-tolerated, not all studies have demonstrated clinical efficacy that is superior to placebo. In addition, the precise neurochemical m...
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